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This enables the oocytes to pause their expansion and enter a holding sample, which lasts in the mouse’s adulthood. In mice missing PRC1, the oocytes didn’t pause their growth; instead, they withered and died in just a thirty day period, leaving the mice completely infertile.

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This protein may well “create and retain the chromatin point out,” claims Namekawa — preserving the spools in position plus the oocytes genetically primed get more info as being the mouse matures.

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